CAS NO:12112-67-3 [Ir(cod)Cl]2/Chloro(1,5-cyclooctadiene)iridium(I) Dimer

1.Pharmaceutical and pesticide synthesis
2. Preparation of functional materials: OLED photovoltaic materials and polymer engineering materials
3. Fine Chemicals: In the synthesis of fine chemicals such as flavors and food additives

Asymmetric hydrogenation reaction.

1. Redox properties
2. Catalytic properties
3. Reactivity and Ligand Dissociation

To form a mononuclear iridium complex and become a highly active and highly enantioselective chiral catalyst, it is necessary to coordinate with chiral bidentate chelating ligands. Such ligands need to satisfy three core characteristics: a rigid chelating framework, precise spatial steric hindrance, and adjustable electronic effect. They can form a stable chiral coordination environment with Ir⁺, thereby achieving stereospecific recognition of the substrate in catalytic hydrogenation. The core ligand type is a chiral phosphine ligand (monophosphine bidentate / phosphine heteroatom bidentate), supplemented by a small amount of chiral nitrogen ligands and chiral carbenes (adapted to specific substrates). Among them, the phosphine - nitrogen (P,N) and phosphine - phosphine (P,P) bidentate chiral ligands are currently the most widely used and have the best catalytic performance.

After the precursor is slightly hygroscopic, it cannot be used directly. The preferred method is to dry it at 40-50℃ under high vacuum and low temperature (the operation is the simplest). If the hygroscopicity is slightly heavier, use the boiling distillation of anhydrous toluene / dichloromethane (the water removal is the most thorough); after processing, it is necessary to detect the moisture content and solubility. Only when it is qualified can it be sealed and stored in an inert atmosphere and used as soon as possible. Throughout the process, avoid high temperature and contact with air to ensure the core performance of the catalytic precursor.